Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 36
Volume 36, Issue -, Pages 411-433Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-042617-053352
Keywords
interleukin-2; JAK1/3; PI3K; cytokine signaling
Categories
Funding
- Wellcome Trust [205023, 097418/Z/11/Z, 205023/Z/16/Z] Funding Source: Medline
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The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both pro-and anti-inflammatory T cells is fundamental to determining the molecular details of immune regulation. The IL-2 receptor couples to JAK tyrosine kinases and activates the STAT5 transcription factors. However, IL-2 does much more than control transcriptional programs; it is a key regulator of T cell metabolic programs. The development of global phosphoproteomic approaches has expanded the understanding of IL-2 signaling further, revealing the diversity of phosphoproteins that may be influenced by IL-2 in T cells. However, it is increasingly clear that within each T cell subset, IL-2 will signal within a framework of other signal transduction networks that together will shape the transcriptional and metabolic programs that determine T cell fate.
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