Journal
ANNUAL REVIEW OF BIOPHYSICS, VOL 47
Volume 47, Issue -, Pages 251-271Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-070317-032955
Keywords
cell size regulation; coarse-grained stochastic models; microbial cell cycle; molecular mechanisms; single-cell variability; population growth
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Most microorganisms regulate their cell size. In this article, we review some of the mathematical formulations of the problem of cell size regulation. We focus on coarse-grained stochastic models and the statistics that they generate. We review the biologically relevant insights obtained from these models. We then describe cell cycle regulation and its molecular implementations, protein number regulation, and population growth, all in relation to size regulation. Finally, we discuss several future directions for developing understanding beyond phenomenological models of cell size regulation.
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