Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 20
Volume 20, Issue -, Pages 277-300Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-062117-121019
Keywords
probiotics; genetic tools; CRISPR; genome engineering; microbiome
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Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [DP2HD091798] Funding Source: NIH RePORTER
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An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies.
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