4.5 Article Book Chapter

Mass Spectrometry for Synthesis and Analysis

Journal

Publisher

ANNUAL REVIEWS
DOI: 10.1146/annurev-anchem-061417-125820

Keywords

ion chemistry; molecular imaging; cancer diagnostics; origin of life; ion soft landing; reaction monitoring; ambient ionization; accelerated reactions

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Mass spectrometry is the science and technology of ions. As such, it is concerned with generating ions, measuring their properties, following their reactions, isolating them, and using them to build and transform materials. Instrumentation is an essential element of these activities, and analytical applications are one driving force. Work from the Aston Laboratories at Purdue University's Department of Chemistry is described here, with an emphasis on accelerated reactions of ions in solution and small-scale synthesis; ion/surface collision processes, including surface-induced dissociation (SID) and ion soft landing; and applications to tissue imaging. Our special interest in chirality and the chemistry behind the origins of life is also featured together with the exciting area of tissue diagnostics.

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