Journal
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 11
Volume 11, Issue -, Pages 197-218Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-anchem-061417-125811
Keywords
electrochemical DNA biosensors; hybridization; DNA-mediated electron transfer; electrochemical beacons; electrocatalytic sensors; redox indicators
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Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other approaches for NA detection. Here, electrode reactions of DNA, basic principles of electrochemical NA analysis, and their relevance for practical applications are reviewed and critically discussed.
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