Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 15, Issue 11, Pages 1285-1297Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737175.2015.1088783
Keywords
Arab; Asia; fluctuations; non-motor; Parkinson's disease; screening tools; wearing-off
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Funding
- Ratchadapiseksompoj Endowment Fund of Chulalongkorn University [RES560530136, RES560530137-HR]
- Chulalongkorn University
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Most Parkinson's disease patients will receive levodopa therapy, and of these, the majority will develop some levodopa-induced complications. For many patients, the first complication to develop is the decline in the duration of therapeutic benefit of each levodopa dose, a phenomenon commonly termed wearing-off'. There is already extensive literature documenting the epidemiology and management of wearing-off in Parkinson's disease patients of western descent. However, data derived from these studies might not always apply to patients of Asian descent due to genetic variations, differences in co-morbidities or non-availability of certain drugs. This review summarizes the current literature regarding the epidemiology of wearing-off in Asian (including Arab) patients and discusses the management issues in the context of drug availability in Asia.
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