Journal
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
Volume 15, Issue 6, Pages 725-733Publisher
EXPERT REVIEWS
DOI: 10.1586/14737159.2015.1041378
Keywords
cancer; exosome; extracellular vesicles; molecular diagnosis; surface plasmon resonance
Categories
Funding
- NIH [R01 HL113156, P01 CA069246, U54 CA151884, T32-CA79443]
- DoD OCRP [W81XWH-14-1-0279]
- B.S.-Ph.D. National Science Scholarship - Agency for Science, Technology and Research, Singapore
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Exosomes have emerged as a promising biomarker. These vesicles abound in biofluids and harbor molecular constituents from their parent cells, thereby offering a minimally-invasive avenue for molecular analyses. Despite such clinical potential, routine exosomal analysis, particularly the protein assay, remains challenging, due to requirements for large sample volumes and extensive processing. We have been developing miniaturized systems to facilitate clinical exosome studies. These systems can be categorized into two components: microfluidics for sample preparation and analytical tools for protein analyses. In this report, we review a new assay platform, nano-plasmonic exosome, in which sensing is based on surface plasmon resonance to achieve label-free exosome detection. Looking forward, we also discuss some potential challenges and improvements in exosome studies.
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