Journal
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
Volume 15, Issue 9, Pages 1143-1158Publisher
TAYLOR & FRANCIS AS
DOI: 10.1586/14737159.2015.1059278
Keywords
communicable diseases; early diagnosis; host-pathogen interactions; metabolome; molecular diagnostics; proteome; respiratory tract infection; sepsis; transcriptome; tuberculosis
Categories
Funding
- NIAID
- Henry Jackson Foundation
- Novartis
- DARPA
- Veteran's Affairs Center [1IK2CX000611]
- Novartis Diagnostics
- BioFire
- bioMerieux
- Nanosphere
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A century of advances in infectious disease diagnosis and treatment changed the face of medicine. However, challenges continue to develop including multi-drug resistance, globalization that increases pandemic risks and high mortality from severe infections. These challenges can be mitigated through improved diagnostics, focusing on both pathogen discovery and the host response. Here, we review how 'omics' technologies improve sepsis diagnosis, early pathogen identification and personalize therapy. Such host response diagnostics are possible due to the confluence of advanced laboratory techniques (e.g., transcriptomics, metabolomics, proteomics) along with advanced mathematical modeling such as machine learning techniques. The road ahead is promising, but obstacles remain before the impact of such advanced diagnostic modalities is felt at the bedside.
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