Journal
RSC ADVANCES
Volume 6, Issue 43, Pages 36923-36931Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra01441k
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Funding
- National Natural Science Foundation of China [21073143]
- Ministry of Education of China [Z2009-1-71002, Z2009-1-71006]
- NPU Foundation for Graduate Innovation
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Two novel metal complexes 2-3 (metal = Pd-II, Pt-II) have been synthesized by reacting the corresponding tolylterpyridine complexes and the 4-aminonaphthalimide derivative 1. The interactions of the complexes with duplex DNA and telomeric G-quadruplex DNA have been investigated by UV-Vis spectroscopy and fluorescence spectroscopy. The studies reveal that the complexes 2-3 possess high affinity and reasonable selectivity for telomeric G-quadruplex DNA over duplex DNA. Spectroscopic and molecular docking studies suggest that the complexes 2-3 interact with telomeric G-quadruplex DNA mainly through groove binding. The compounds 1-3 are emissive (Phi(em) > 0.22), making it possible to study the localization of 1-3 in A549 using fluorescence microscopy. The complexes 2-3 are mainly localized in nuclei, while 1 is localized in the nuclei and cytoplasmic region after 0.5 h incubation. The complex 3 inhibits A549 cells selectively over non-cancerous NIH3T3 cells, with higher antitumor activity than 1 and cisplatin.
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