Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 12, Issue 1, Pages 79-89Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2016.1100965
Keywords
miRNA; melanoma; tumor microenvironment; metastasis; exosomes
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The crosstalk of melanoma cells with components of the microenvironment promotes malignant cell proliferation and spread to distant tissues. Although the major pathogenetic events have already been elucidated, the mechanisms that drive the metastatic behavior of tumor cells are still undefined. MicroRNAs (miRNAs) are small non-coding RNAs that control post-transcriptional gene expression through interconnected kinases upstream of functional genes involved in tumor progression. Here, we review the biological relevance of melanoma-related miRNAs and focus on their potential role in propagating signals that may cause tumor microenvironment rearrangements, as well as disablement of the immune system and melanoma cell proliferation.
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