Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 11, Issue 3, Pages 377-389Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2015.1008453
Keywords
complement; cytokines; dendritic cells; innate immunity; monocytes; Toll-like receptors; transplantation
Categories
Funding
- Kidney Research Scientist Core Education and National Training (KRESCENT) Program New Investigator Award from Kidney Foundation of Canada [KRES12002]
- Canadian Institutes of Health Research [KRI123890, PCL134068]
- FQRS [26726]
- Department of Medicine from Laval University
Ask authors/readers for more resources
Innate immunity is increasingly recognized as a major player in transplantation. In addition to its role in inflammation in the early post-transplant period, innate immunity shapes the differentiation of cells of adaptive immunity, with a capacity to promote either rejection or tolerance. Emerging data indicate that innate allorecognition, a characteristic previously limited to lymphocytes, is involved in allograft rejection. This review briefly summarizes the physiology of each component of the innate immune system in the context of transplantation and presents the current or promising therapeutic applications, such as cellular, anticomplement and anticytokine therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available