Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 11, Issue 7, Pages 849-857Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2015.1043893
Keywords
chronic inflammation; colorectal cancer; hepatocellular carcinoma; inflammatory bowel disease; leukemia; neoplastic disease; non small cell lung cancer; TREM-1; TREM-2; triggering receptor expressed on myeloid cells
Categories
Funding
- Office of the Director of National Institutes of Health [R01 HL106042, R01 HL112597, R01 HL120659]
- National Heart Lung and Blood Institute, NIH, USA
Ask authors/readers for more resources
Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, the triggering receptor expressed on myeloid cells has been implicated in disease severity and progression. In this article, the current understanding of triggering receptor expressed on myeloid cells function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available