Journal
RSC ADVANCES
Volume 6, Issue 51, Pages 45963-45967Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra05148k
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Funding
- National Natural Science Foundation of China [21472199]
- NSFC-Joint Foundation of Yunnan Province [U1202222]
- National Science Fund for Distinguished Young Scholars [81525026]
- State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P2016-ZZ02]
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Applanatumols A (1) and B [(+/-)-2], two unique meroterpenoids with a novel spiro[ benzofuran-2,2'-bicyclo [3.2.2]nonane] ring system and a naturally unusual dioxacyclopenta[cd]inden motif, respectively, were isolated from Ganoderma applanatum. Their structures were determined using spectroscopic data. In particular, the absolute configurations of 1 and 2 were assigned by X-ray diffraction analysis using the Flack parameter and ECD calculations, respectively. A plausible biosynthetic pathway for 1 and 2 is proposed. The biological activities of 1 and 2 against renal fibrosis were accessed in rat proximal tubular epithelial cells.
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