Journal
ANNALS OF NEUROLOGY
Volume 83, Issue 5, Pages 1027-1031Publisher
WILEY
DOI: 10.1002/ana.25234
Keywords
-
Categories
Funding
- Colonial Foundation
- St Vincent's Hospital Research Endowment Fund
- National Health and Medical Research Council [1103238]
- Victorian Government
- Australian Government Research Training Program Scholarship
- Lions International
- Medical Research Council of Great Britain [MC_UU_12024/1]
- National Health and Medical Research Council of Australia [1103238] Funding Source: NHMRC
- MRC [MC_UU_12024/1] Funding Source: UKRI
- Medical Research Council [MC_UU_12024/1] Funding Source: researchfish
Ask authors/readers for more resources
Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes. Ann Neurol 2018;83:1027-1031
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
