Journal
ANNALS OF NEUROLOGY
Volume 83, Issue 1, Pages 197-204Publisher
WILEY
DOI: 10.1002/ana.25117
Keywords
-
Categories
Funding
- NIH [UL1 TR000448, KL2 TR000450]
- National Institute on Aging [R03 AG047999, K76 AG054863, P50 AG05681, P01 AG26276]
- National Institute of Neurological Disorders and Stroke [R01 NS065667]
- National Institute of General Medical Sciences [P41 GM103422]
- National Institute of Diabetes and Digestive and Kidney Diseases [P30 DK056341]
- McDonnell Center for Systems Neuroscience at Washington University School of Medicine
- MetLife Foundation Award
- Cambridge Isotope Laboratories
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [KL2TR002346, UL1TR000448, KL2TR000450, UL1TR002345] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK056341] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P41GM103422] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS065667] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P50AG005681, P01AG026276, R03AG047999, K76AG054863] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid beta, suggesting a mechanism for sleep disturbances to increase Alzheimer disease risk. We tested this response in humans using indwelling lumbar catheters to serially sample cerebrospinal fluid while participants were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. All participants were infused with C-13(6)- leucine to measure amyloid beta kinetics. We found that sleep deprivation increased overnight amyloid beta 38, amyloid beta 40, and amyloid beta 42 levels by 25 to 30% via increased overnight amyloid b production relative to sleeping controls. These findings suggest that disrupted sleep increases Alzheimer disease risk via increased amyloid b production.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available