Related references
Note: Only part of the references are listed.The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways
A. Slominski et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Emerging trends in the epidemiology of melanoma
V. Nikolaou et al.
BRITISH JOURNAL OF DERMATOLOGY (2014)
Cancer Statistics, 2014
Rebecca Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2014)
A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
Gopinath Sutendra et al.
CELL (2014)
Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism
Yi Xuan et al.
EXPERIMENTAL CELL RESEARCH (2014)
TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X-Irradiation
Helena Populo et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)
Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition
Cecilie Abildgaard et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2014)
The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
Shuai Zhang et al.
NUTRITION & METABOLISM (2014)
Dabrafenib: First Global Approval
Anita D. Ballantyne et al.
DRUGS (2013)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
JOURNAL OF CLINICAL INVESTIGATION (2013)
Mitochondrial activation by inhibition of PDKII suppresses HIF1α signaling and angiogenesis in cancer
G. Sutendra et al.
ONCOGENE (2013)
Expression parameters of the metabolic pathway genes pyruvate dehydrogenase kinase-1 (PDK-1) and DJ-1/PARK7 in renal cell carcinoma (RCC)
Daniel Baumunk et al.
WORLD JOURNAL OF UROLOGY (2013)
Targeting cellular metabolism to improve cancer therapeutics
Y. Zhao et al.
CELL DEATH & DISEASE (2013)
Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene
Arnaldur Hall et al.
ONCOTARGET (2013)
GNAQ and BRAF mutations show differential activation of the mTOR pathway in human transformed cells
Helena Populo et al.
PEERJ (2013)
Melanoma: From Melanocyte to Genetic Alterations and Clinical Options
Corine Bertolotto
SCIENTIFICA (2013)
Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
Jerome Kluza et al.
CANCER RESEARCH (2012)
Insights into melanoma: targeting the mTOR pathway for therapeutics
Helena Populo et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2012)
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
Liesbeth C. W. Vredeveld et al.
GENES & DEVELOPMENT (2012)
Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
Keith T. Flaherty et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973
Andreas R. Baudy et al.
EJNMMI RESEARCH (2012)
Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer
Chun-Wun Lu et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Anticancer drugs that target metabolism: is dichloroacetate the new paradigm?
Ioanna Papandreou et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
Comparative Metabolic Flux Profiling of Melanoma Cell Lines BEYOND THE WARBURG EFFECT
David A. Scott et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
Ramon C. Sun et al.
MOLECULAR CANCER (2011)
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
Paul B. Chapman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
mTOR pathway activation in cutaneous melanoma is associated with poorer prognosis characteristics
H. Populo et al.
PIGMENT CELL & MELANOMA RESEARCH (2011)
Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia
Siranoush Shahrzad et al.
CANCER LETTERS (2010)
Constitutive HIF-1 activity in malignant melanoma
Silke Kuphal et al.
EUROPEAN JOURNAL OF CANCER (2010)
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
F. Stephen Hodi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Metabolic Modulation of Glioblastoma with Dichloroacetate
E. D. Michelakis et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104
Rob A. Cairns et al.
CLINICAL CANCER RESEARCH (2009)
Mitochondrial Mutations Contribute to HIF1α Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck Squamous Cell Carcinoma
Wenyue Sun et al.
CLINICAL CANCER RESEARCH (2009)
Final Version of 2009 AJCC Melanoma Staging and Classification
Charles M. Balch et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
S. M. Wigfield et al.
BRITISH JOURNAL OF CANCER (2008)
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
Chun-Wun Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Causes and consequences of increased glucose metabolism of cancers
Robert J. Gillies et al.
JOURNAL OF NUCLEAR MEDICINE (2008)
Understanding signaling cascades in melanoma
Pablo Lopez-Bergami et al.
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2008)
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Bradly G. Wouters et al.
NATURE REVIEWS CANCER (2008)
Mutant V600E BRAF increases hypoxia inducible factor-1α expression in melanoma
Suresh M. Kumar et al.
CANCER RESEARCH (2007)
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
Sebastien Bonnet et al.
CANCER CELL (2007)
Regulation of the pyruvate dehydrogenase complex
MS Patel et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Histologic criteria for diagnosing primary cutaneous malignant melanoma
BR Smoller
MODERN PATHOLOGY (2006)
Precursors to melanoma and their mimics: nevi of special sites
DE Elder
MODERN PATHOLOGY (2006)
PAX8-PPAR gamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma
P Castro et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
BRAFE600-associated senescence-like cell cycle arrest of human naevi
C Michaloglou et al.
NATURE (2005)
Multifaceted roles of glycolytic enzymes
JW Kim et al.
TRENDS IN BIOCHEMICAL SCIENCES (2005)
BRAF mutations are common somatic events in melanocytic nevi
R Kumar et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2004)
Share Paper
