Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms17010079
Keywords
Briareum; briarenolide; briarane; gorgonian; anti-inflammatory; iNOS
Funding
- Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- National Museum of Marine Biology and Aquarium
- National Dong Hwa University
- Ministry of Science and Technology [NSC 103-2911-I-002-303, MOST 104-2911-I-002-302, 103-2325-B-039-008, 103-2325-B-039-007-CC1, 103-2325-B-291-001, 104-2325-B-291-001, 104-2320-B-291-001-MY3, NSC 101-2320-B-291-001-MY3]
- National Health Research Institutes [NHRI-EX103-10241BI]
- Chinese Medicine Research Center, China Medical University (Ministry of Education, Aim for the Top University Plan), Taiwan
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Six new 9-hydroxybriarane diterpenoids, briarenolides ZI-ZVI (1-6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1-6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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