Journal
EMERGING INFECTIOUS DISEASES
Volume 22, Issue 6, Pages 964-972Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2206.151752
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Funding
- National Science Fund for Distinguished Young Scholars [81525023]
- US National Institutes of Health [U19 AI51915]
- Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences [U54 GM088558]
- Health and Medical Research Fund of the Health, Welfare and Food Bureau of the Hong Kong SAR Government [14131432]
- Research Grants Council of the Hong Kong Special Administrative Region, China [T11-705/14N]
- Health and Medical Research Fund of the Health, Welfare and Food Bureau of the Hong Kong SAR Government
- MedImmune Inc.
- Sanofi Pasteur
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Since March 2013, a novel influenza A(H7N9) virus has caused 3 epidemic waves of human infection in mainland China. We analyzed data from patients with laboratory confirmed influenza A(H7N9) virus infection to estimate the risks for severe outcomes after hospitalization across the 3 waves. We found that hospitalized patients with confirmed infections in waves 2 and 3 were younger and more likely to be residing in small cities and rural areas than were patients in wave 1; they also had a higher risk for death, after adjustment for age and underlying medical conditions. Risk for death among hospitalized patients during waves 2 and 3 was lower in Jiangxi and Fujian Provinces than in eastern and southern provinces. The variation in risk for death among hospitalized case-patients in different areas across 3 epidemic waves might be associated with differences in case ascertainment, changes in clinical management, or virus genetic diversity.
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