Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 36, Pages 11662-11666Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201805968
Keywords
capsules; colloidosomes; controlled release; Pickering emulsions
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Funding
- Hong Kong Special Administration Region (HKSAR) General Research Fund [CUHK14306617, 2130535]
- Faculty of Science of the Chinese University of Hong Kong, China
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Colloidosomes have received considerable attention for the controlled delivery of active ingredients in medicine, agrochemicals, and cosmetics. However, most reported colloidosomes are highly permeable and size is larger than 1 mu m. All silica colloidosomes have now been prepared with adjustable size, compact shell and low permeability. Our approach is based on the formation of inverse water-in-oil (w/o) emulsions stabilized solely by hydrophobic silica nanoparticles and subsequent locking of the particle at the oil-water interface by a simple sol-gel reaction of silica precursor at room temperature. The colloidosomes obtained display a robust and closed shell, ensuring a long-term retention of small hydrophilic molecules such as Methylene Blue. Remarkably, unlike all other reported silica colloidosomes, a timely and stepwise release of the encapsulated cargo can be triggered by adding ethanol or surfactant without destroying the capsule shell.
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