Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 11, Pages 2827-2830Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201711868
Keywords
arenes; bioinorganic chemistry; protein modifications; rhodium; transition metals
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Funding
- NSF [CHE-1609654, CHE-1055569]
- Robert A. Welch Foundation [C-1680]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1609654] Funding Source: National Science Foundation
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Metal-based bioconjugation linkages represent a little-studied approach to protein functionalization that provides novel reactivity, stability, and function. Described is an organometallic bioconjugation, employing rhodium(III) salts, to link boronic acids with tyrosine residues by an arene complex. Both peptides and proteins are amenable to the mild bioconjugation in aqueous media, allowing incorporation of useful functionalities, such as affinity handles or fluorophores. Because of the metastability of the inorganic linkage, the conjugates are susceptible to cleavage by nucleophilic redox mediators but are stable toward typical biological conditions.
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