Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 17, Pages 4752-4755Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800954
Keywords
copper-binding peptides; ion channels; ion-selective nanopores; self-assembled monolayers; sensors
Categories
Funding
- Lendulet program of the Hungarian Academy of Sciences [OTKA NN117637, LP2013-63]
Ask authors/readers for more resources
We report the synthesis and analytical application of the first Cu2+-selective synthetic ion channel based on peptide-modified gold nanopores. A Cu2+-binding peptide motif (Gly-Gly-His) along with two additional functional thiol derivatives inferring cation-permselectivity and hydrophobicity was self-assembled on the surface of gold nanoporous membranes comprising of about 5nm diameter pores. These membranes were used to construct ion-selective electrodes (ISEs) with extraordinary Cu2+ selectivities, approaching six orders of magnitude over certain ions. Since all constituents are immobilized to a supporting nanoporous membrane, their leaching, that is a ubiquitous problem of conventional ionophore-based ISEs was effectively suppressed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available