Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 14, Pages 3622-3625Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712428
Keywords
boron; C-C bond formation; cross-coupling; nickel; umpolung
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Funding
- ICIQ
- MINECO [CTQ2015-65496-R]
- MINECO (Severo Ochoa Accreditation) [SEV-2013-0319]
- Cellex Foundation
- Severo Ochoa
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A nickel-catalyzed reductive arylation of ambiphilic -bromoalkyl boronic esters with aryl halides is described. This platform provides an unrecognized opportunity to promote the catalytic umpolung reactivity of ambiphilic reagents with aryl halides, thus unlocking a new cross-coupling strategy that complements existing methods for the preparation of densely functionalized alkyl-substituted organometallic reagents from simple and readily accessible precursors.
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