Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 26, Pages 7691-7696Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800354
Keywords
chemo-photodynamic therapy; hydrogen-bonded organic frameworks; singlet oxygen generation; structural stability; pi-stacking interactions
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Funding
- National Natural Science Foundation of China (NSFC) [21520102001, 21521061, 21331006, 9162214]
- Key Research Program of Frontier Science, CAS [QYZDJ-SSW-SLH045]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- NSFC [21441008]
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The low structural stability of hydrogen-bonded organic frameworks (HOFs) is a thorny issue retarding the development of HOFs. A rational design approach is now proposed for construction of a stable HOE The resultant HOF (PFC-1) exhibits high surface area of 2122 m(2) g(-1) and excellent chemical stability (intact in concentrated HCl for at least 117 days). A new method of acid-assisted crystalline redemption is used to readily cure the thermal damage to PFC-1. With periodic integration of photoactive pyrene in the robust framework, PFC-1 can efficiently encapsulate Doxorubicin (Doxo) for synergistic chemo-photodynamic therapy, showing comparable therapeutic efficacy with the commercial Doxo yet considerably lower cytotoxicily. This work demonstrates the notorious stability issue of HOFs can be properly addressed through rational design, paving a way to develop robust NOR and offering promising application perspectives.
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