Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 30, Pages 9320-9324Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803540
Keywords
glycopeptides; glycosylation; isomers; mass spectrometry; sialic acids
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Funding
- Inga-Britt and Arne Lundberg research foundation
- Knut and Alice Wallenberg foundation
- Swedish research council [8266]
- Kempe foundation
- Deutsche Forschungsgemeinschaft (DFG) [WE 4751/2-1]
- Fonds der Chemischen Industrie [Li 184/01]
- Ministerium fur Kultur und Wissenschaft des Landes Nordrhein-Westfalen
- Regierende Burgermeister von Berlininkl
- Sahlgrenska University Hospital
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Distinct structural changes of the alpha 2,3/alpha 2,6-sialic acid glycosidic linkages on glycoproteins are of importance in cancer biology, inflammatory diseases, and virus tropism. Current glycoproteomic methodologies are, however, not amenable toward high-throughput characterization of sialic acid isomers. To enable such assignments, a mass spectrometry method utilizing synthetic model glycopeptides for the analysis of oxonium ion intensity ratios was developed. This method was successfully applied in large-scale glycoproteomics, thus allowing the site-specific structural characterization of sialic acid isomers.
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