Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 30, Pages 9238-9261Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800343
Keywords
Baeyer-Villiger oxidation; biocatalysis; halogenation; oxidation; oxyfunctionalisation
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Funding
- European Research Commission (ERC) [648026]
- European Union [H2020-BBI-PPP-2015-2-1-720297]
- Netherlands Organisation for Scientific Research (VICI) [724.014.003]
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Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H bonds. For many of these reactions, no classical chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes based on a more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. In this Review, we critically summarise the most important recent developments in the field of biocatalytic oxidation chemistry and identify the most pressing bottlenecks as well as promising solutions.
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