Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 11, Pages 2768-2798Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201700171
Keywords
caged compounds; chemical biology; optochemical tools; photochemistry; photoswitches
Categories
Funding
- National Science Foundation Graduate Research Fellowship
- Mellon Graduate Fellowship
- National Institutes of Health [GM112728, GM108952, HD085206]
- National Science Foundation [CHE-1404836, CBET-1603930, MCB-1330746]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R21HD085206] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM112728, R01GM108952] Funding Source: NIH RePORTER
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Biological processes are naturally regulated with high spatial and temporal control, as is perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively utilized in cell and developmental biology to investigate cellular processes, and conditional control methods have expanded applications of these technologies toward resolving complex biological questions. Light represents an excellent external trigger since it can be controlled with very high spatial and temporal precision. To this end, several optically regulated tools have been developed and applied to living systems. In this review we discuss recent developments of optochemical tools, including small molecules, peptides, proteins, and nucleic acids that can be irreversibly or reversibly controlled through light irradiation, with a focus on applications in cells and animals.
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