Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 33, Pages 10574-10578Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201804895
Keywords
anti-counterfeiting technologies; biomedical implants; information-containing macromolecules; sequence-defined polymers; sequencing
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Funding
- H2020 program of the European Union (project Euro-Sequences, H2020-MSCA-ITN-2014) [642083]
- SATT Conectus Alsace (project Poltag)
- CNRS
- ITN Euro-Sequences
- ANR project Nanocardiorop [ANR-15-CE08-0019-03]
- ANR project [00111001, ANR-16-CE29-0004-02]
- Spectropole
- FEDER [OBJ2142-3341]
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Sequence-defined oligourethanes were tested as invivo taggants for implant identification. The oligomers were prepared in an orthogonal solid-phase iterative approach and thus contained a coded monomer sequence that can be unequivocally identified by tandem mass spectrometry (MS/MS). The oligomers were then included in small amounts (1wt%) in square-centimeter-sized crosslinked poly(vinyl alcohol) (PVA) model films, which were intramuscularly and subcutaneously implanted in the abdomen of rats. After one week, one month, or three months of implantation, the PVA films were explanted. The rat tissues exposed to the implants did not exhibit any adverse reactions, which suggested that the taggants are not harmful and probably not leaching out from the films. Furthermore, the explanted films were immersed in methanol, as a solvent for oligourethanes, and the liquid extract was analyzed by mass spectrometry. In all cases, the oligourethane taggant was detected, and its sequence was identified by MS/MS.
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