Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 9, Pages 2377-2382Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712453
Keywords
carbon dots; cellular energy metabolism; chirality; glycolysis; green synthesis
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Funding
- National Basic Research Program of China [2013CB834502]
- National Natural Science Funds for Distinguished Young Scholars [31325010, 21425416]
- NSFC [91543127, 31571021]
- NSFC Innovation Team [11621505, 21421064]
- Key Research Program of CAS [KGZD-EW-T06]
- K. C. Wong Education Foundation
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Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26%) based on hydrothermal treatment of l-or d-cysteine at as low as 60 degrees C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with L-CDs showed up-regulated glycolysis, while D-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.
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