Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 14, Pages 3626-3630Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712528
Keywords
colon cancer; fluorescence; invivo imaging; nanoprobes; second near-infrared window
Categories
Funding
- National Science Foundation of China [21672062, 21421004, 11675251, 21390414]
- Programme of Introducing Talents of Discipline to Universities [B16017]
- National Key R&D Program of China [2016YFA0201200, 2016YFA0400900]
- CAS [QYZDJ-SSW-SLH031]
Ask authors/readers for more resources
Fluorescent probes in the second near-infrared window (NIR-II) allow high-resolution bioimaging with deep-tissue penetration. However, existing NIR-II materials often have poor signal-to-background ratios because of the lack of target specificity. Herein, an activatable NIR-II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2S-activated ratiometric fluorescence and light-up NIR-II emission at 900-1300nm. By using this activatable and target specific probe for deep-tissue imaging of H2S-rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR-II probes will find widespread applications in biological and clinical systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available