Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 18, Pages 4995-4999Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800667
Keywords
cyclization; nitrogen heterocycles; radical; samarium; urea
Categories
Funding
- EPSRC
- Leverhulme Trust
- University of Manchester
- EPSRC [EP/L00125X/1, EP/P001386/1] Funding Source: UKRI
Ask authors/readers for more resources
Radical anions generated from urea carbonyls by reductive electron transfer are exploited in carbon-carbon bond formation. New radical cyclizations of urea radical anions deliver complex nitrogen heterocycles and, depending upon the proton source used in the reactions, a chemoselective switch between reaction pathways can deliver two heterobicyclic scaffolds. A computational study has been used to investigate the selectivity of the urea radical processes. Furthermore, radical cyclization cascades involving urea radical anions deliver unusual spirocyclic aminal architectures.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available