Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 10, Pages 2958-2978Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201804067
Keywords
cubosomes; drug delivery; lipids; nanoparticles; self-assembly
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Funding
- H2020 through the Individual Marie Sklodowska-Curie Fellowship SmartCubes [703666]
- FP7 Marie Curie Intra-European Fellowship SMase LIPOSOME [626766]
- Swiss National Science Foundation [P300PA_171540]
- i-sense Engineering and Physical Sciences Research Council (EPSRC) IRC in Early Warning Sensing Systems for Infectious Diseases [EP/K031953/1]
- EPSRC [EP/K020641/1, EP/J017566/1]
- ERC [616417]
- Swedish Foundation of Strategic Research through the Industrial Research Centre FoRmulaEx [IRC15-0065]
- Swiss National Science Foundation (SNF) [P300PA_171540] Funding Source: Swiss National Science Foundation (SNF)
- EPSRC [EP/K020641/1, EP/K031953/1, EP/J017566/1] Funding Source: UKRI
- European Research Council (ERC) [616417] Funding Source: European Research Council (ERC)
- Marie Curie Actions (MSCA) [703666] Funding Source: Marie Curie Actions (MSCA)
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Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Bicontinuous lipid cubic phases consist of a single lipid bilayer that forms a continuous periodic membrane lattice structure with pores formed by two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, the polymer outer corona can be used for targeting and they are highly stable under physiological conditions. Compared to liposomes, the structure provides a significantly higher membrane surface area for loading of membrane proteins and small drug molecules. Owing to recent advances, they can be engineered in vitro in both bulk and nanoparticle formats with applications including drug delivery, membrane bioreactors, artificial cells, and biosensors. This review outlines recent advances in cubosome technology enabling their application and provides guidelines for the rational design of new systems for biomedical applications.
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