Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 6, Pages 1557-1562Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201711044
Keywords
click chemistry; glycopolymers; oxygen tolerance; PET-RAFT; photomediated radical polymerization
Categories
Funding
- Busch Biomedical Seed Grant
- American Cancer Society-Institutional Research Grant Early Investigator Pilot Award
- UNSW
- Australian Research Council (ARC) [DE170100315]
- ARC [FT12010096]
Ask authors/readers for more resources
The complexity of polymer-protein interactions makes rational design of the best polymer architecture for any given biointerface extremely challenging, and the high throughput synthesis and screening of polymers has emerged as an attractive alternative. A porphyrin-catalysed photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerisation was adapted to enable high throughput synthesis of complex polymer architectures in dimethyl sulfoxide (DMSO) on low-volume well plates in the presence of air. The polymerisation system shows remarkable oxygen tolerance, and excellent control of functional 3-and 4-arm star polymers. We then apply this method to investigate the effect of polymer structure on protein binding, in this case to the lectin concanavalin A (ConA). Such an approach could be applied to screen the structure-activity relationships for any number of polymer-protein interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available