Related references
Note: Only part of the references are listed.GuideScan software for improved single and paired CRISPR guide RNA design
Alexendar R. Perez et al.
NATURE BIOTECHNOLOGY (2017)
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
Evan A. Boyle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly
Shaofeng Liu et al.
SCIENCE (2017)
Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9
Peiwu Qin et al.
NATURE COMMUNICATIONS (2017)
Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
Fuqiang Chen et al.
NATURE COMMUNICATIONS (2017)
Tracking Multiple Genomic Elements Using Correlative CRISPR Imaging and Sequential DNA FISH
Juan Guan et al.
BIOPHYSICAL JOURNAL (2017)
Landscape and mechanisms of transcription factor cooperativity
Joana Osorio
NATURE REVIEWS GENETICS (2016)
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker et al.
SCIENCE (2016)
Imaging Specific Genomic DNA in Living Cells
Baohui Chen et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 45 (2016)
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
David A. Nelles et al.
CELL (2016)
Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin
Jigar N. Bandaria et al.
CELL (2016)
Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres
Jens C. Schmidt et al.
CELL (2016)
Editing DNA Methylation in the Mammalian Genome
X. Shawn Liu et al.
CELL (2016)
Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering
Addison V. Wright et al.
CELL (2016)
CRISPR-Cas9 nuclear dynamics and target recognition in living cells
Hanhui Ma et al.
JOURNAL OF CELL BIOLOGY (2016)
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
Josh Tycko et al.
MOLECULAR CELL (2016)
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver et al.
NATURE (2016)
Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow
Hanhui Ma et al.
NATURE BIOTECHNOLOGY (2016)
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
Christopher D. Richardson et al.
NATURE BIOTECHNOLOGY (2016)
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
John G. Doench et al.
NATURE BIOTECHNOLOGY (2016)
Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system
Shipeng Shao et al.
NUCLEIC ACIDS RESEARCH (2016)
Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci
Baohui Chen et al.
NUCLEIC ACIDS RESEARCH (2016)
CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci
Yi Fu et al.
NATURE COMMUNICATIONS (2016)
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
Digvijay Singh et al.
NATURE COMMUNICATIONS (2016)
A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation
Iman Farasat et al.
PLOS COMPUTATIONAL BIOLOGY (2016)
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
R. Stefan Isaac et al.
ELIFE (2016)
Cas9 Functionally Opens Chromatin
Amira A. Barkal et al.
PLOS ONE (2016)
An RNA-aptamer-based two-color CRISPR labeling system
Siyuan Wang et al.
SCIENTIFIC REPORTS (2016)
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
Jesse G. Zalatan et al.
CELL (2015)
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
Bernd Zetsche et al.
CELL (2015)
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
Lauren R. Polstein et al.
GENOME RESEARCH (2015)
Chromatin architecture reorganization during stem cell differentiation
Jesse R. Dixon et al.
NATURE (2015)
Conformational control of DNA target cleavage by CRISPR-Cas9
Samuel H. Sternberg et al.
NATURE (2015)
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Silvana Konermann et al.
NATURE (2015)
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
Xiaoling Wang et al.
NATURE BIOTECHNOLOGY (2015)
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
Isaac B. Hilton et al.
NATURE BIOTECHNOLOGY (2015)
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
Miguel A. Moreno-Mateos et al.
NATURE METHODS (2015)
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
Daesik Kim et al.
NATURE METHODS (2015)
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
Henriette O'Geen et al.
NUCLEIC ACIDS RESEARCH (2015)
Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
Ritambhara Singh et al.
NUCLEIC ACIDS RESEARCH (2015)
Multicolor CRISPR labeling of chromosomal loci in human cells
Hanhui Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells
Wulan Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Dynamics of CRISPR-Cas9 genome interrogation in living cells
Spencer C. Knight et al.
SCIENCE (2015)
CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites
Yuki Naito et al.
BIOINFORMATICS (2015)
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2015)
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
Richard L. Frock et al.
NATURE BIOTECHNOLOGY (2015)
In the right place at the right time: visualizing and understanding mRNA localization
Adina R. Buxbaum et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Looping Back to Leap Forward: Transcription Enters a New Era
Michael Levine et al.
CELL (2014)
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Luke A. Gilbert et al.
CELL (2014)
Development and Applications of CRISPR-Cas9 for Genome Engineering
Patrick D. Hsu et al.
CELL (2014)
The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones
Thomas R. Cech et al.
CELL (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells
Lior Nissim et al.
MOLECULAR CELL (2014)
CRISPR-P: A Web Tool for Synthetic Single-Guide RNA Design of CRISPR-System in Plants
Yang Lei et al.
MOLECULAR PLANT (2014)
Programmable RNA recognition and cleavage by CRISPR/Cas9
Mitchell R. O'Connell et al.
NATURE (2014)
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Samuel H. Sternberg et al.
NATURE (2014)
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
Xuebing Wu et al.
NATURE BIOTECHNOLOGY (2014)
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
Cem Kuscu et al.
NATURE BIOTECHNOLOGY (2014)
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
John G. Doench et al.
NATURE BIOTECHNOLOGY (2014)
Dynamic regulation of transcriptional states by chromatin and transcription factors
Ty C. Voss et al.
NATURE REVIEWS GENETICS (2014)
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre
Ezgi Hacisuleyman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Targeting and tracing of specific DNA sequences with dTALEs in living cells
Katharina Thanisch et al.
NUCLEIC ACIDS RESEARCH (2014)
Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
Mark D. Szczelkun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The new frontier of genome engineering with CRISPR-Cas9
Jennifer A. Doudna et al.
SCIENCE (2014)
CRISPR-based technologies: prokaryotic defense weapons repurposed
Rebecca M. Terns et al.
TRENDS IN GENETICS (2014)
Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system
Tetsushi Sakuma et al.
SCIENTIFIC REPORTS (2014)
Transcription activator-like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing
Ning Sun et al.
BIOTECHNOLOGY AND BIOENGINEERING (2013)
The Cell Biology of Genomes: Bringing the Double Helix to Life
Tom Misteli
CELL (2013)
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Baohui Chen et al.
CELL (2013)
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
Luke A. Gilbert et al.
CELL (2013)
DNA repair mechanisms in dividing and non-dividing cells
Teruaki Iyama et al.
DNA REPAIR (2013)
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu et al.
NATURE BIOTECHNOLOGY (2013)
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Vikram Pattanayak et al.
NATURE BIOTECHNOLOGY (2013)
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Kevin M. Esvelt et al.
NATURE METHODS (2013)
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
Matthew H. Larson et al.
NATURE PROTOCOLS (2013)
Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data
Job Dekker et al.
NATURE REVIEWS GENETICS (2013)
Live visualization of chromatin dynamics with fluorescent TALEs
Yusuke Miyanari et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors
Hanhui Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Spatial Dynamics of Chromosome Translocations in Living Cells
Vassilis Roukos et al.
SCIENCE (2013)
Dynamics and Memory of Heterochromatin in Living Cells
Nathaniel A. Hathaway et al.
CELL (2012)
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Giedrius Gasiunas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller et al.
NATURE BIOTECHNOLOGY (2011)
An unbiased genome-wide analysis of zinc-finger nuclease specificity
Richard Gabriel et al.
NATURE BIOTECHNOLOGY (2011)
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
Vikram Pattanayak et al.
NATURE METHODS (2011)
Chromosome Organization by a Nucleoid-Associated Protein in Live Bacteria
Wenqin Wang et al.
SCIENCE (2011)
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
Michelle Christian et al.
GENETICS (2010)
Genome editing with engineered zinc finger nucleases
Fyodor D. Urnov et al.
NATURE REVIEWS GENETICS (2010)
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
Jens Boch et al.
SCIENCE (2009)
A Simple Cipher Governs DNA Recognition by TAL Effectors
Matthew J. Moscou et al.
SCIENCE (2009)
HatoTag: A novel protein labeling technology for cell imaging and protein analysis
Georgyi V. Los et al.
ACS CHEMICAL BIOLOGY (2008)
Histone modifications and nuclear architecture:: A review
Eva Bartova et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2008)
Live cell imaging of repetitive DNA sequences via GFP-tagged polydactyl zinc finger proteins
Beatrice I. Lindhout et al.
NUCLEIC ACIDS RESEARCH (2007)
Beyond the sequence: Cellular organization of genome function
Tom Misteli
CELL (2007)
Fluorescent DNA nanotags: Supramolecular fluorescent labels based on intercalating dye arrays assembled on nanostructured DNA templates
Andrea L. Benvin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Genetics of global gene expression
Matthew V. Rockman et al.
NATURE REVIEWS GENETICS (2006)
Use of two-color fluorescence-tagged transgenes to study interphase chromosomes in living plants
AJM Matzke et al.
PLANT PHYSIOLOGY (2005)
Fluorescence in situ hybridization: past, present and future
JM Levsky et al.
JOURNAL OF CELL SCIENCE (2003)
Transcription regulation and animal diversity
M Levine et al.
NATURE (2003)
Nuclear architecture - Visualizing chromatin dynamics in interphase nuclei
SM Gasser
SCIENCE (2002)
Stimulation of homologous recombination through targeted cleavage by chimeric nucleases
M Bibikova et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
The HP1 protein family: getting a grip on chromatin
JC Eissenberg et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2000)
Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
J Smith et al.
NUCLEIC ACIDS RESEARCH (2000)
Share Paper
