Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 6, Pages 1663-1667Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710731
Keywords
aldehydes; difluoromethylthioesters; fluorine; radical reactions; reaction mechanisms
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Funding
- National Natural Science Foundation of China [NSFC-21572178, NSFC-21702162]
- Natural Science Basic Research Plan in Shaanxi Province of China [2017JM2006]
- Key Science and Technology Innovation Team of Shaanxi Province [2017KCT-37]
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Difluoromethylthioester compounds are yet another important kind of organofluorine compound and are reported here for the first time. They can be efficiently synthesized from various aldehydes. The synthetic method features mild reaction conditions, good tolerance of functional groups, broad substrate scope, and importantly, no metal is involved in the reaction. The approach has the potential to become an important tool for the late-stage functionalization of advanced synthetic intermediates, and should have many applications in medicinal chemistry.
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