Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 44, Pages 14440-14475Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201804971
Keywords
antibacterials; antibiotics; antivirulence; chemical biology; natural products
Categories
Funding
- Deutsche Forschungsgemeinschaft [SI 1096/10-1]
- German National Academic Foundation
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The public view on antibiotics as reliable medicines changed when reports about resistant superbugs appeared in the news. While reasons for this resistance development are easily spotted, solutions for re-establishing effective antibiotics are still in their infancy. This Review encompasses several aspects of the antibiotic development pipeline from very early strategies to mature drugs. An interdisciplinary overview is given of methods suitable for mining novel antibiotics and strategies discussed to unravel their modes of action. Select examples of antibiotics recently identified by using these platforms not only illustrate the efficiency of these measures, but also highlight promising clinical candidates with therapeutic potential. Furthermore, the concept of molecules that disarm pathogens by addressing gatekeepers of virulence will be covered. The Review concludes with an evaluation of antibacterials currently in clinical development. Overall, this Review aims to connect select innovative antimicrobial approaches to stimulate interdisciplinary partnerships between chemists from academia and industry.
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