Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 15, Pages 3938-3942Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712550
Keywords
afterglow; nanoparticles; photothermal therapy; semiconducting polymer nanococktail
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Funding
- Nanyang Technological University [NTUSUG: M4081627.120]
- Singapore Ministry of Education [RG133/15 M4011559, 2015-T1-002-091, MOE2016-T2-1-098]
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Nanoparticles for photothermal therapy: Real-time temperature monitoring is critical to reduce the nonspecific damage during photothermal therapy (PTT); however, PTT agents that can emit temperature-related signals are rare and limited to few inorganic nanoparticles. We herein synthesize a semiconducting polymer nanococktail (SPNCT) that can not only convert photo-energy to heat but also emit temperature-correlated luminescence after cessation of light excitation. Such an afterglow luminescence of the SPNCT detects tumors more sensitively than fluorescence as a result of the elimination of tissue autofluorescence, while its temperature-dependent nature allows tumor temperature to be optically monitored under near-infrared (NIR) laser irradiation. Thus, SPNCT represents the first organic optical nanosystem that enables optical-imaging guided PTT without real-time light excitation.
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