Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 25, Pages 7488-7492Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201801248
Keywords
circularly polarised luminescence spectroscopy; lanthanides; luminescence; nucleotides; zinc
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Funding
- Durham University
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A series of three europium complexes bearing picolyl amine moieties was found to possess differing binding affinities towards Zn2+ and three nucleotides: AMP, ADP, and ATP. A large increase in the total emission intensity was observed upon binding Zn2+, followed by signal amplification upon the addition of nucleotides. The resulting adducts possessed strong induced circularly polarised emission, with ADP and ATP signals of opposite sign. Model DFT geometries of the adducts suggest the diastereoisomer is preferred for ATP and the isomer for ADP/AMP. This change in sign allows the ADP/ATP (or AMP/ATP) ratio to be assessed by monitoring changes in the emission dissymmetry factor, g(em).
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