Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 24, Pages 7156-7160Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803804
Keywords
aluminium; hydrides; lithium; reduction; sustainability
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Funding
- University Erlangen-Nurnberg
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Imine-to-amine conversion with catalytic instead of stoichiometric quantities of LiAlH4 is demonstrated (85 degrees C, catalyst loading2.5mol%, pressure1bar). The effects of temperature, pressure, solvent, and catalyst modifications, as well as the substrate scope are discussed. Experimental investigations and preliminary DFT calculations suggest that the catalytically active species is generated insitu: LiAlH4+Ph(H)C=NtBuLiAlH(2)[N(tBu)CH2Ph](2). A cooperative mechanism in which Li and Al both play a prominent role is proposed.
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