Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 24, Pages 7111-7115Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803029
Keywords
electrostatic complexes; enzyme-responsive polymers; host-guest systems; self-assembly; self-immolation
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Funding
- U.S. National Science Foundation [CHE-1740597]
- Turkish Government
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We report a new molecular design strategy that allows for the propagation of surface enzymatic events inside a supramolecular assembly for accelerated molecular release. The approach addresses a key shortcoming encountered with many of the currently available enzyme-induced disassembly strategies, which rely on the unimer-aggregate equilibria of amphiphilic assemblies. The enzymatic response of the host to predictably tune the kinetics of guest-molecule release can be programmed by controlling substrate accessibility through electrostatic complexation with a complementary polymer. Accelerated guest release in response to the enzyme is shown to be accomplished by a cooperative mechanism of enzyme-triggered supramolecular host disassembly and host reorganization.
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