Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 36, Pages 11522-11531Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201805138
Keywords
hypoxia; oxygen delivery; photodynamic therapy; tumors
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Funding
- National Research Foundation of Korea (NRF) - government of Korea (MSIP) [2012R1A3A2048814]
- Ministry of Science and Technology (MOST) of China [2016YFA0201200]
- National Natural Science Foundation of China [51525203, 51761145041]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- National Research Foundation of Korea [2012R1A3A2048814] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.
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