Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 9, Pages 2334-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710415
Keywords
alkenylboronates; asymmetric catalysis; cyclopropanes; copper; hydroboration
Categories
Funding
- MINECO [CTQ2014-52769-C03-01-R]
- Junta de Andaluca [P12-FQM-1765]
Ask authors/readers for more resources
A novel, highly enantio- and diastereoselective synthesis of 1-boryl-2,3-disubstituted cyclopropanes has been developed by means of the cyclopropanation of alkenylboronates with ethyl diazoacetate in the presence of catalytic amounts of a chiral copper(I) complex. The products can also be directly accessed from alkynes through an operationally simple, sequential hydroboration-cyclopropanation protocol. The resulting enantioenriched 1-boryl-2,3-disubstituted cyclopropanes are versatile synthetic intermediates that undergo further transformations at the carbon-boron bond.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available