Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 9, Pages 2497-2501Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712235
Keywords
arenes; C-H activation; Fujiwara-Moritani reaction; olefination; palladium
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Funding
- Max Planck Society
- FCI
- Alexander von Humboldt Foundation
- WWU Munster
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The application of the Pd-catalyzed oxidative C-H olefination of arenes, also known as the Fujiwara-Moritani reaction, has traditionally been limited by the requirement for directing groups on the substrate or the need to use the arene in large excess, typically as a (co)solvent. Herein the development of a catalytic system is described that, through the combined action of two complementary ligands, makes it possible to use directing-group-free arenes as limiting reagents for the first time. The reactions proceed under a combination of both steric and electronic control and enable the application of this powerful reaction to valuable arenes, which cannot be utilized in excess.
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