Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 13, Pages 3381-3385Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201713207
Keywords
annulation; C-H activation; decarboxylation; multicomponent reactions; palladium
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Funding
- National Natural Science Foundation of China [21602172]
- CUHK [4053237]
- RGC of Hong Kong [153367/16P, C5023-14G]
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A regioselective aromatic -extension reaction of internal alkynes is reported. The proposed method employs three easily available components, namely aryl halides, 2-haloarylcarboxylic acids, and disubstituted acetylenes. The transformation is driven by a controlled reaction sequence of C-H activation, decarboxylation, and annulation to give poly(hetero)aromatic compounds in a site-selective fashion. Unlike in previously reported palladium-catalyzed three-component annulations, alkyne carbopalladation is the last step of this tandem reaction.
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