Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 16, Pages 4412-4428Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707816
Keywords
checkpoint inhibitor; combination therapy; kinase inhibitors; small molecules; T-cells
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Immuno-oncology therapies have the potential to revolutionize the armamentarium of available cancer treatments. To further improve clinical response rates, researchers are looking for novel combination regimens, with checkpoint blockade being used as a backbone of the treatment. This Review highlights the significance of small molecules in this approach, which holds promise to provide increased benefit to cancer patients.
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