Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 28, Pages 8421-8424Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201802189
Keywords
cystinuria; dynamic networks; pseudopeptides; sensors; systems chemistry
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Funding
- MINECO/FEDER [CTQ2015-70117-R, BES-2013-063128]
- AGAUR [2014 SGR 231]
- European Union [COST CM1304]
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The study of molecular networks represents a conceptual revolution in chemistry. Building on previous knowledge and after understanding the rules of non-covalent interactions, the design of stimulus-responsive chemical systems is possible. Herein we report a new strategy, based on the reorganization of a dynamic chemical network that generates new fluorescent associations in the presence of cysteine or cystine. The binding and sensing units are encoded in the components that dynamically assemble and disassemble responding to external stimuli as a successful tool to detect both cysteine and cystine in aqueous media. Moreover, the dynamic sensing system works in human urine, as a prospective application for cystinuria diagnosis.
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