Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 33, Pages 10489-10493Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201801318
Keywords
dissipative self-assembly; DNA devices; DNA nanotechnology; supramolecular chemistry; temporal control
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Funding
- European Research Council, ERC [336493]
- Associazione Italiana per la Ricerca sul Cancro, AIRC [14420]
- Italian Ministry of Health [GR-2010-2317212]
- Italian Ministry of University and Research (Project of National Interest, PRIN) [2012CTAYSY]
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Supramolecular chemistry is moving into a direction in which the composition of a chemical equilibrium is no longer determined by thermodynamics but by the efficiency with which kinetic states can be populated by energy consuming processes. Herein, we show that DNA is ideally suited for programming chemically fueled dissipative self-assembly processes. Advantages of the DNA-based systems presented in this study include a perfect control over the activation site for the chemical fuel in terms of selectivity and affinity, highly selective fuel consumption that occurs exclusively in the activated complex, and a high tolerance for the presence of waste products. Finally, it is shown that chemical fuels can be used to selectively activate different functions in a system of higher complexity embedded with multiple response pathways.
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