Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 13, Pages 3488-3492Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800699
Keywords
energy transfer; heterocycles; nickel; photocatalysis; sulfonamides
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Funding
- NIH General Medical Sciences (Grant NIHGMS) [R01 GM103558-05]
- Seoul National University
- NRF of Korea [2017 R1A2B3002869]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM103558] Funding Source: NIH RePORTER
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Herein we report a highly efficient method for nickel-catalyzed C-N bond formation between sulfonamides and aryl electrophiles. This technology provides generic access to a broad range of N-aryl and N-heteroaryl sulfonamide motifs, which are widely represented in drug discovery. Initial mechanistic studies suggest an energy-transfer mechanism wherein C-N bond reductive elimination occurs from a triplet excited Ni-II complex. Late-stage sulfonamidation in the synthesis of a pharmacologically relevant structure is also demonstrated.
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