Enhanced peroxidase-like activity of Mo-doped ceria nanoparticles for sensitive colorimetric detection of glucose

The development of highly efficient nanomaterial-based mimetic enzymes is much needed to replace natural enzymes due to their low cost, high stability and efficient catalytic ability. Herein, multiple Mo-doped CeO2 nanoparticles (Mo/CeO2 NPs) with different molar ratios of Mo were synthesized using a facile microwave-assisted method. For characterizing the as-prepared Mo/CeO2 NPs, XRD, TEM, HRTEM, BET and XPS have been performed systematically. The peroxidase-like activity of Mo/CeO2 NPs was investigated, and they exhibited enhanced peroxidase-like activity in comparison to that of pure CeO2 NPs, the best peroxidase-like activity was obtained for the Mo/CeO2 NPs when the molar ratio of Mo was 9%. On the basis of the high activity of Mo/CeO2 NPs, the reaction provides a simple, sensitive and selective method for colorimetric detection of glucose with the detection limit of 4 x 10(-7) mol L-1 and in a dynamic range from 5 x 10(-7) to 5 x 10(-5) mol L-1. This work will pave a way for high throughput synthesis of other ultra-small doped metal oxide nanoparticles, which have bright prospects in biomedical analysis.