Journal
ANALYTICAL CHEMISTRY
Volume 90, Issue 15, Pages 9510-9514Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b02195
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Funding
- National Research Foundation of Korea [2012R1A3A2048814, 2016R1E1A1A02920873]
- National Natural Science Foundation of China [21708041]
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The ratiometric fluorescent probe B6S, which contains pyrene as a fluorophore and imidazoline-2-thione as a reactive site, was developed for detection of hypochlorite (OCl-). B6S displays a high specificity toward OCl(- )in contrast to other reactive oxygen species and reactive nitrogen species. The probe has a low detection limit and operates under biological conditions. Moreover, the low cytotoxicity of B6S enables it to be utilized effectively for OCl- imaging in living cells and tissues by using two-photon microscopy. The findings indicate that B6S has the capability of serving as a probe to explore the biological functions of OCl- in living systems.
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