Journal
ANALYTICAL CHEMISTRY
Volume 90, Issue 3, Pages 2070-2078Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.7b04312
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Funding
- National Key Research and Development Program of China [2016YFF0203704, 2016YFF0100301]
- National Natural Science Foundation of China [21390410, 21621003, 21705091, 21727813]
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In this work, we demonstrate a novel design that allows rapid online identification and quantitation of unsaturated fatty acid C=C location isomers via epoxidation and ambient mass spectrometry (MS). Unsaturated fatty acid solution was loaded on a paper strip placed between a low-temperature plasma probe and the inlet of a mass spectrometer. Reactive oxygen species in the plasma promoted epoxidation at the C=C, and the product was simultaneously ionized. Upon collision-induced dissociation (CID), the epoxidation product was fragmented to release diagnostic ions specific to the C=C location. The whole analytical workflow can be completed within 5 s and is particularly promising for point-of-care (POC) clinical diagnosis, considering its fast, high-throughput nature, and coupling with paper-based analytical devices.
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